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Platform Technology

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HumaMAX®

Inside-the-body immunoregulatory platform technology using the characteristics of γ-PGA,
a new immunity-controlling material for medicine

Core source technology utilizing γ-PGA, which enhances the activation of natural killer cells by using a high-molecular substance created by a microorganism called "Bacillus subtilis" to stimulate immunocytes in the intestinal mucosal membrane.

New medicine development platform technology based on the immunoregulatory effects of a natural amino acid high-molecular refined substance, "γ-PGA (Poly-γ-glutamic Acid)"

  • A structure in which glutamic acid, a necessary type of amino acid, is repetitively connected through gamma-peptide bonds
  • Its mechanism is an immunoregulatory effect : TLR4 as a medium ① Induces innate immunity ② Strengthens adaptive immunity ③ Improves the tumor microenvironment (TEM) in a favorable manner

"Bacillus subtilis Chungkookjang," a GRAS (Generally recognized as safe) microorganism

  • Produced with a patented strain

Medicine under development and diseases to be treated

  • Extended application for more diseases : A combined treatment of tumor with Immune Checkpoint Blockade (ICB), cell therapy products, etc.

Poly-γ-glutamic acid (γ-PGA)

  • An edible amino acid, high-molecular material, and a natural substance found in bean-fermented foods such as Korea's very own
    "cheonggukjang"
  • Produced by Bacillus subtilis Chungkookjang, a type of GRAS (generally recognized as safe) microorganism with edible safety established
    (MOAlifeplus's patented strain)
  • Though it is a natural substance, a mass production system for γ-PGA of high molecular weight (2,000 kDa on average) has been established
    through a fermentation and refinement processes (certified as one of Korea's Top 10 New Technologies)
  • Increase in immunoreaction via γ-PGA, effective against cancer, viruses, and inflammation diseases
  • γ-PGA also has several health-related functions including moisturization, acceleration of mineral absorption, and inhibited activation of
    the lyase of hyaluronic acid, which is a tissue component inside the body